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KMID : 0352719930170020123
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Journal of Ginseng Research
1993 Volume.17 No. 2 p.123 ~ p.126
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Increase in Hepatic DT-Diaphorase Activity by Chronic Administration of Panax ginseng Extract to Mice
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이강미
위명복/송동근/김용식/김영희
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Abstract
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Effects of chronic administration of ginseng extracts (30 or 150mg/kg/day for 52 days. P. o) to mice on the activities of DT-diaphorase and glutathione S-transferase (GST) in the liver and the brain were studied. The DT-diaphorase activity in the
liver
was increased over 2-fold at the dose of both 3- and 150mg/kg/day, while there was no change in the activity of the enzyme in the brain The GST activity in the liver was increased in dose-dependent fashion upto 142% of the control value at the
dose
of
150mg/kg/day, while there was no change in the activity of the enzyme in the brain. The ginseng-induced increase in the activities of these hepatic phase II drug-metabolizing enzymes which are involved in the detoxification of carcinogens, is
suggested
to underlie, at least in part, the anticarcinogenic activity of Panax ginseng.
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